The Bauer Research Foundation was established to promote the drug discovery work of Joseph A. Bauer, Ph.D. Dr. Bauer has been a cancer researcher for more than ten years. His work has resulted in three United States Patents (one pending) and over twenty-five foreign patents which pertain to these compounds. Dr. Bauer's Professional Biography can be found at:http://gozips.uakron.edu/~jbauer/
Specifically, Dr. Bauer developed a vitamin B12 -based compound, nitrosylcobalamin (NO-Cbl), (United States Patent # 5,936,082) at the University of Akron, Akron, Ohio.
NO-Cbl is a derivative of vitamin B12 that occurs in nature. Several human and animal studies have shown that vitamin B12 (hydroxocobalamin) will scavenge nitric oxide naturally in vivo.
Research studies involving NO-Cbl were recently featured in the Cleveland Clinic Magazine in an article about “Smart Medicine” www.clevelandclinic.org/clevelandclinicmagazine/pdf/winter_05.pdf
Currently, the Bauer Research Foundation (BRF) is working to provide NO-Cbl, a vitamin B12 derivative (shown to occur naturally in animals) available for research use.
Nitric Oxide Donors as Anti-tumor Agents
The anti-tumor properties of NO-Cbl are based on the mechanisms of action of nitric oxide (NO) to initiate apoptosis (programmed cell death).
NO-Cbl is in the family of compounds known as nitric oxide (NO) donors. NO has been shown to kill cancer cells in vitro and in vivo by numerous research groups across the world. Two of the earliest NO donors, glyceryl trinitrate (GTN) and sodium nitroprusside (SNP) have been around since the 1800s. GTN was first used in humans to treat angina since the 1870s. SNP was first used in humans in 1928. As both GTN and SNP produce NO, the biochemical basis exists that these compounds can be utilized to fight cancer. Both compounds are commercially available. A drawback to the use of conventional NO donors is that they lack tumor targeting and if administered systemically would lead to hypotension. However, these compounds may be used to deliver NO to tumors but would require injecting the compounds directly into the tumor. A drawback of SNP is cyanide production which can be de-toxified by the liver. Information about these compounds and their experimental use in possibly treating cancer can be found at www.pubmed.gov or by searching Google. Please consult your veterinarian for advice and possible treatment options.
Dr. Dongho Seo is a licensed veterinarian that is familar with using SNP to treat canine tumors using a trans-dermal rub (goes thru the skin). He practices at Smith Ridge Veterinary Clinic http://www.smithridge.com/. Dr. Seo can be contacted at drseosmihridge@gmail.com
Alternative Treatment Options
Please consult with your veterinary as side-effects are not known.
1. Neoplasene is available from BuckMountainBotanicals.com . Dr. Fox, Ph.D. produced the compound and requires a prescription from your vet.
2. Condurango is produced by IBERHOME- they recommend 4 pills / 2 times in a day. If the dog is large 8 pills/ 2 times in a day. They also sell a liquid form that can be added to your pets dinking water.
4. Green tea can be added to the drinking water as well. A search of www.pubmed.gov of "green tea and cancer" produces more than 3000 references. Green tea has at least two known components that have anti-cancer properties. Or a green tea extract can be added to the drinking water to avoid caffeine- http://www.wonderlabs.com/itemleft.php?itemnum=5091 - 4 capsules daily (2 in the am, 2 in the pm)
It is important to understand that because of the complexities of cancer, no single agent including NO-Cbl, will ever be "the cure" for cancer. The cure for cancer will be achieved by a combination of many factors including dietary considerations, compounds that prevent blood supply to tumors (anti-angiogenic), biological therapies such as interferons and TRAIL, immune system modulators, traditional cytotoxic agents, radiation, and targeted therapies such as histone deacetylase inhibitors, tyrosine kinase inhibitors, and anti-tumor vaccines to name a few.
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June 27, 2009
Read the first, formal research studies evaluating NO-Cbl in dogs:
The first dog was treated with NO-Cbl more than five years ago. Diagnosed with an extremely aggressive form of cancer called anal sac adenocarcinoma, Oscar’s future seemed bleak. Bedridden and unresponsive to chemotherapy or radiation, he would be lucky to survive three months. But thanks to NO-Cbl, Oscar’s cancer receded and he was walking again within two weeks.
Oscar’s recovery was extraordinary enough, but his case was unusual for another reason. Oscar is a Bichon Frise, who scientists and veterinarians call “the Miracle Dog.” While it gives profound hope to dog owners, NO-Cbl also points to a powerful new cancer treatment for humans — one that infiltrates cancer cells like a biological Trojan horse. Oscar has been off-treatment for two years now and is cancer-free.
The Cleveland Clinic is currently using NO-Cbl to treat several dogs that have incurable cancer.
The information contained in this website is intended to supplement, not substitute for,the expertise and judgment of your veterinarian. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that the use of NO-Cbl in treating your pet is safe, appropriate or effective. NO-Cbl has not been approved or tested by the Food and Drug Administration or the Center for Veterinary Medicine.
